50 Cent has reportedly been admitted to hospital with a stomach virus.
The In Da Club rapper tweeted a picture of himself surrounded by cuddly toys - including a giraffe, and elephant and a lion - in his bed, saying he wasn't looking forward to being operated on.
Alongside the picture, he tweeted: "I don't want to go into surgery."
Appealing to his friend, champion boxer Floyd Mayweather, for support, he added: "@FloydMayweather call my phone why your phone off. (sic)"
XXL Magazine reported 50 was suffering a stomach virus, and while Mayweather wasn't specific about his pal's illness, he asked fans to pray for him.
He told US radio station V103's Ryan Cameron: "Please keep 50 Cent in your prayers he is in the hospital and he is extremely sick ... we will remain positive."
Although he is claiming to be ill, 50 reassured fans his latest release is ready.
He tweeted: "I'm in the hospital but my gangsta grillz LOST TAPE is done so it will be out on time. (sic)"
Mayweather also found time to joke, posting a message under another picture his rap friend posted of him watching an old TV from his bed: "While you're in the hospital they need to get you a flat screen TV."